A New Approach to Traumatic Brain Injury

Traumatic brain injury, or TBI, is a wound that is difficult to comprehend and impossible to see from the outside, and affects a more diverse set of individuals than one might think.

Active-duty military and veterans are the most obvious population to endure TBI. They most often suffer from the condition as a result of training and combat exposure over time. However, the condition affects athletes and civilians at an alarming rate as well.

According to the Centers for Disease Control and Prevention, 1.5 million Americans experience TBI annually. The symptoms of TBI often manifest as anxiety, depression, anger, and cognitive issues. Traditional treatments have sought to address these symptoms with conventional therapy and medication. Unfortunately, this approach often only exacerbates TBI, instead of attacking the underlying cause of the condition. While the medical and scientific literature has been available for years, it hasn’t been applied to TBI until now.

Dr. Mark Gordon, a physician who has been practicing endocrinology for the past 20 years, has focused his efforts on TBI. Endocrinology relates to the endocrine system which is responsible for controlling hormones, which are important chemical messengers.

Gordon himself has endured at least six separate head traumas in his lifetime. Years ago, his TBI led to clinical depression. In the course of his own research, he discovered a novel way to treat his injury. After undergoing laboratory tests, he found that he had hormonal deficiencies that were causing his depression. He believed the inflammation in his brain from his multiple head traumas was the underlying cause.

While Gordon was in throes of depression, he read a book on hormones. He had lab tests done, and found that he had deficiencies in testosterone, thyroid, and growth hormone. Once these hormones were restored to healthier levels, he began to feel better.

Gordon
Dr. Mark Gordon discusses TBI on The Joe Rogan Experience podcast. (Cinema Libre Studio)

Gordon’s first head trauma occurred when he was 4 years old. At age 13, he was hit by a car while riding his bicycle. Three separate car accidents and eight years of martial arts also took their toll. The minor traumas to the brain add up over time in combination with significant accidents, and all contribute to TBI.

“You can either have 10 dimes or a dollar. They both equal a hundred,” Gordon explained.

Inflammation and Hormones

It wasn’t until Gordon was in his mid- to late-40s that he started to develop issues. Throughout his research, he discovered that people can develop TBI as late as 17 years after their injury. TBI creates inflammation, which changes brain chemistry; that change can manifest as depression, anxiety, insomnia, or a host of other symptoms.

In 2004, Gordon was preparing a lecture on the brain and hormones. He stumbled upon a couple of articles, one of which was from Turkey. In this specific treatise, researchers found that there were severe hormone deficiencies in boxers that were leading to mood and personality issues. It seemed that inflammation in the brain caused pituitary issues that, in turn, led to anger, anxiety, depression, and other conditions. Originally trained as a family physician, neuroendocrinology now commanded his attention.

“That was my epiphany article or my ah-ha moment,” Gordon said.

 

Marr
Andrew Marr was a U.S. Army Special Forces engineer and is the founder of the Warrior Angels Foundation. (Courtesy of Andrew Marr)

Gordon’s orthopedic work as a physician led him to work in the NFL. He treated retired players from 1997 through 2007, and his work drove him to start treating active duty military in 2009. Through the course of his work, he met a Green Beret named Andrew Marr.

Marr was a Special Forces engineer and had spent a large part of his career detonating and disposing of explosives. On his fourth tour of duty in Afghanistan, a large explosion knocked him unconscious. However, it would be the cumulative effect of small explosions over time that ultimately triggered his TBI.

Marr had undergone a variety of treatments, and at one point was on more than a dozen medications. Furthermore, he was struggling with alcoholism and opioid addiction to cope with the anxiety and depression his TBI had been causing. The two met in 2015, and Gordon ran his bloodwork.

After discovering that Marr had hormone deficiencies, he began a treatment plan based on hormone therapy and natural supplements and showed massive improvement. He and his brother Adam recount the experience in their book “Tales From the Blast Factory” and now work to connect other veterans to Gordon and his treatment method at Millennium Health.

The results from Gordon’s other patients also have been promising. According to a 2019 summary report on 459 individuals, 78 percent of them considered themselves 50 percent improved by the end of the year, and 4.6 percent were 100 percent better. The 10 to 20 percent who felt that they hadn’t benefited from the protocol were the individuals who had been on the most medications.

Results also showed that age doesn’t seem to play a factor in TBI recovery. The oldest patient was an 84-year-old Vietnam veteran who reported feeling 100 percent better following his treatment protocol.

Marr
Andrew Marr with his wife and seven children. (Courtesy of Andrew Marr)

While Marr’s TBI was the result of a history of explosions, the condition can occur from certain medications, radiation, and surgery that also can cause brain inflammation. One doesn’t have to lose consciousness to develop the condition. Moreover, you don’t need to have symptoms of a concussion to have a traumatic brain injury.

While direct physical blows to the head are the most obvious cause, TBI can also be caused by psychological conditions such as post-traumatic stress.

“That’s why you can have a person who has never had any physical trauma, a person who’s never been to war, never played sports, but gets into a situation where they’re under chronic stress,” Gordon said.

Contact Sport

It’s not just veterans, pugilists, or NFL players who are suffering. Julianna Harpine, 29, is a physical therapist in Pennsylvania and one of the subjects of “Quiet Explosions: Healing the Brain.” For 13 years, she was a competitive gymnast. Concussions weren’t discussed in the gymnastics world, and she didn’t expect head injuries to be a risk of the sport. However, she would experience several blows to the head.

“I always get, ‘Well, gymnastics isn’t a contact sport.’ People forget gymnastics is a contact sport—with the ground,” Harpine said.

While a freshman in high school, she endured her first diagnosed concussion. She was tumbling and flew out of a pass, hitting the back of her head on the floor. She took some ibuprofen, and went back to practice. The next night, she blacked out in midair, and landed flat on her face.

Harpine experienced sensitivity to light and noise for seven months following her concussion. Over time, she had several smaller concussions, and in 2013, she experienced another severe blow to the head in competition.

Following her last concussion, Harpine began experiencing depression, anxiety, and suicidal thoughts. Both the physical and psychological symptoms of TBI had a significant impact on her daily life. She had just been accepted to graduate school, but often missed school and work.

“You can’t see it by looking at someone. When people looked at me, they saw a healthy 20-something-year-old girl. What they didn’t see were the struggles internally or the struggles behind closed doors. After a while, you just try to do life to the best of your ability, but they don’t see what happens outside of you showing up and slapping a smile across your face,” Harpine said.

Harpine underwent conventional treatments, and ended up on a plethora of medications, as Marr had. But the meds only worsened her symptoms. In the spring of 2014, a family friend introduced her to Gordon and his treatment protocol, which she responded to with incredible success.

“I got my energy back, my personality back. I wasn’t fighting to stay awake anymore. I was able to function again. I was able to go back to work and back to school,” Harpine said.

A Wider Audience

Emmy Award-winning director Jerri Sher was contacted by a friend who was working on Marr’s book. She knew Sher had a passion for documentaries about social issues, and urged her to read the book and adapt it into a film. When Sher and Marr met, he gave her the rights to make a movie based on “Tales From the Blast Factory.”

Sher agreed to do the movie under one condition: the subjects of the film would be one-third military, one-third athletes, and one-third civilians. She also needed to speak with Gordon. After their discussions, she learned that his successes weren’t getting enough public attention.

Sher herself has experience in the world of TBI. Her husband contended with the condition after open heart surgery 24 years ago. During the surgery, his brain was deprived of oxygen. Afterward, he began experiencing many similar symptoms that surface for veterans and athletes with TBI.

Her documentary, “Quiet Explosions: Healing the Brain,” sheds light on TBI through interviews with 10 individuals including Harpine, Marr, Gordon, and other medical experts. The film offers insights into a diverse array of patients and paints a vivid picture of what TBI looks like.

“I knew that I could make a huge impact by telling this story through the medium of film,” Sher said.

Article credit: The Epoch Times

Season’s Greetings from AJT!

While Christmas and ringing in the New Year will be different this year for many of us, I am more appreciative than ever that, after a long and very tough year, the holiday season is upon us. The hopefulness and joy of the season feel especially important this year.

Personally AJT has much to be thankful for this year, ever more so, more people have started to see the value in preventive care and wellness, something which we have been advocating for and developing, since the beginning of our medical wellness consulting and management journey in 2013.

Medical Wellness, the new luxury or should we say necessity? This pandemic has amplified people’s determination to lead healthier lives, fuelling demand for better lifestyle, medical, foods, environment, and wellness products.

We see 2021 as a year, where we as individuals, and a society, look towards wellness as a vital connecting piece in anything that we do, and everywhere that we go.

As owners, medical providers, hoteliers, real estate developers, and as industry leaders, we must be mindful to constantly innovate and create with this in mind, while ensuring every project, development or campaign serves this higher purpose of truly improving people’s health and overall wellbeing.

This will allow for sustainability and longevity for all.

On behalf of everyone here, I’d like to take this opportunity to wish you and your family a happy and safe holiday season. We look forward to serving and partnering with you in the coming year!

Best wishes,
Anthony Jude Tan, Founder

 

Newsletter: https://mailchi.mp/74a9854571a3/seasons-greetings-christmas-new-year-ajt-wellity-drmap-medical-wellness-service-providers

Southeast Asia Hotel Investors’ Summit (SEAHIS) 2020

Organised by HOFTEL, the world’s only global hotel owners’ alliance, which also organises the annual Gulf and Indian Ocean Hotel Investors’ Summit (GIOHIS), the Southeast Asia Hotel Investors’ Summit (SEAHIS) will hold its 4th edition on the 1st and 2nd of December, fielding top-level speakers from ASEAN’s hotel and hospitality industry.

REGISTER: https://seahis.com/registration/

Breakout rooms – Wednesday – 2nd December 2020 – 12:30 – 13:15 (TH time)

Has “the illness” destroyed Wellness? Where does the Thai wellness sector go from here?

Speakers:

Anthony Jude Tan, Founder, AJT Holdings

Roland Bleszynski, Founder & Director, Abode Development Co., Ltd.

SEAHIS 2020 will take place 1 to 2 December 2020 at the Hyatt Regency Bangkok Sukhumvit.
View newsletter here: https://mailchi.mp/af9c85916af6/seahis2020ajtwellnessanthonyjudetanfounder

Aksorn Rayong Thailand Hotel

August 2018, Blog Article from MIDA Assests

 

MIDA Assets Public Company Limited (MIDA) joins hands with Wellity, a leading hospitality management company in Singapore. Launched a joint venture company “MW WELLNESS MANAGEMENT” (MW Wellness Management) penetrates the real estate development market, leads the trend, launches the first Concept Hotel, “Aksorn Rayong The Wellity Collection “the first and only new resort style in Rayong Which brings art and culture with holistic wellbeing together with facilities seamlessly with uniquely superior service standards,

Mr. Wisoot Eeosivikul Chairman and Managing Director of MIDA Assets Public Company Limited (MIDA) revealed that MIDA’s joint venture with Wellity is another milestone for the company. And it creates opportunities to offer new types of services that are different from other international hotel chains.

“We spent more than 20 million baht in a joint venture with Wellity to set up MW WELLNESS MANAGEMENT and invested over a billion to build a hotel.” AKSORN RAYONG, THE WELLITY COLLECTION (Aksorn Rayong, The Wellity Collection. ) ”It is the first hotel managed by MW WELLNESS MANAGEMENT, which is expected to spend approximately 35 million baht in this project for health equipment and essential components in various elements. Of the company Use a proactive marketing strategy By focusing on the strengths that are unique to We combine the elements of holistic wellness with every service. On the hotel side according to international standards Whether it is the place, the room, the health center, the treatment program Including food and drink In which our hotel guests can experience a feeling of comfort and health at the same time.

Anthony Jude Tan, Chief Executive Officer of Wellity, revealed that this joint venture to establish MW WELLNESS MANAGEMENT is another important step towards expanding both Wellity and MIDA businesses. A new pick for investors who want to build an integrated service business and aks of Rayong, The Wellness Collection is a new phenomenon in the hotel and resort business in Thailand. That brings new innovations In the healthcare industry, it is fully integrated with facilities with superior service standards. At Aksorn Rayong, The Wealthy Collection, our guests will experience the first hotel concept. And a unique experience throughout the stay “

“Currently, MW WELLNESS MANAGEMENT has two hotels under its management,“ Aksorn ”, an art and cultural theme, and“ The Wellity Collection ”is a medical element for health. Combined with hotel and resort services, “Aksorn Rayong The Wellness Collection” is the first hotel that brings the strengths of both “Aksorn” and “The Wellity Collection”. ”Come together And emerged as a new concept hotel that is unique, Aksorn Rayong is expected to open in August this year and from 2019 onwards with a business development plan under management. The addition of MW WELLNESS MANAGEMENT is The Panaro, a condominium project in Phuket and Tara Pathom, a Thai villa. Which apart from the market in Thailand We will begin to expand to many of the neighboring countries, “Anthony added

business character.
MIDA The Company and its subsidiaries are principally engaged in the sale and hire purchase of electric appliances. And used cars, hotels, golf courses, billboards rental Real estate development business Manage transferred assets, non-performing assets of financial institutions And security service business

 

Source: MIDA Assets

Global Professionals Summit 2020

The Covid-19 pandemic was an unprecedented event that took the world by surprise. Not only did it cost lives, it has also cost several livelihoods. As businesses attempt to survive and thrive in the new normal, new skills are needed and old ones become obsolete.

The Global Professionals Summit (GPS) initiative was conceived by the International Youth Society (Singapore) with the Young Entrepreneurs Society (Singapore) to promote relevant learning and skills development. It spawned from a dire need as the world begins to reboot from turmoil of the global economic crisis and disruptions to the way of life to almost all walks of life.

Business leaders, academia and global experts are invited to this event to share about the new mindset, new skillset, business trends and opportunities.

Youths around the world need to reposition themselves as the economy resets and equip themselves with an updated mindset and skills to remain relevant for employment or as entrepreneurs in the “New Normal”.

Founder and Group MD, Anthony Jude Tan shared his experience on How to Become An Entrepreneur, Business Ethics, and What Investors Look For.
Online event took place on Saturday, 26 September 2020

AJT Holdings partner, Swan & Maclaren’s new book tells stories behind iconic Singapore landmarks

Swan & Maclaren: A Story Of Singapore Architecture, written by architectural historian and anthropologist Julian Davison, explores the architectural firm’s works from 1892 to today, including the Teutonia Club, now known as Goodwood Park Hotel (abo

Swan & Maclaren: A Story Of Singapore Architecture, written by architectural historian and anthropologist Julian Davison, explores the architectural firm’s works from 1892 to today, including the Teutonia Club, now known as Goodwood Park Hotel (above). PHOTOS: SWAN & MACLAREN, ST FILE

Some of the country’s landmarks are featured in a new book by Singapore architectural firm Swan & Maclaren

 

Singapore’s oldest architectural practice Swan & Maclaren has, after more than 120 years, finally published a comprehensive tome of its works from 1892 till today.

Written by architectural historian and anthropologist Julian Davison, Swan & Maclaren: A Story Of Singapore Architecture is a hefty 440-page glossy coffee-table collectible jointly published with the National Archives of Singapore (NAS).

 

 

Traumatic Brain Injuries (TBI) Wrongly Diagnosed as Post-traumatic Stress Disorder

AJT Holdings’ recognizes Group Lead Medical Director, Dr. Mark L. Gordon’s great dedication, and efforts towards helping soldiers with TBI. You are an amazing inspiration to the team. Thank you.

 

Thousands of British troops ‘have untreated brain injuries after being blown up’

EXCLUSIVE: Doctors and scientists warn failure to properly treat troops with blast-­related trauma is national scandal as many are wrongly diagnosed and at risk of suicide

Thousands of British soldiers could be suffering from ­untreated brain injuries after being blown up while serving in Iraq and Afghanistan, the Sunday People can reveal.Doctors and scientists say the failure to properly treat troops with blast-­related traumatic brain injuries is a national scandal.

Many of those suffering have been wrongly diagnosed with post-traumatic stress disorder and could now be at risk of suicide and depression. The Sunday People has also learned that three members of the SAS were forced to pay for their own flight to the United States to get treatment not ­available in the UK. The Ministry of Defence’s treatment of traumatic brain injury is based on a 10-day course where patients are taught how to cope with the symptoms.

 

But in the United States, soldiers have brain scans using new technology and are then treated with hormones which can repair damaged brain tissue.

One UK trauma psychotherapist who works with wounded troops believes the failure to properly treat brain damage has led to a surge in military suicides. US defence chiefs believe that up to 20 per cent of all troops who served in Iraq and Afghanistan could have a ­traumatic brain injury (TBI). America’s Defence and Veterans Brain Injury Centre has reported that more than 400,000 troops have ­suffered it since 2000. By comparison, the MoD says that only 737 troops have been diagnosed with TBI after ­serving in the same wars. Around 180,000 British troops served in Iraq and Afghanistan over the last  17 years and many did ­multiple tours.

 

Even a conservative ­estimate based on the US percentage shows that thousands of serving and former troops could have TBI and need help. Experts claim the disparity in figures is because the British military does not screen for TBI after combat. Psychotherapist Mandy Bostwick said: “There is plenty of evidence from internationally ­renowned scientists showing that blast TBI is now the signature injury of the Iraq and Afghanistan wars. “There is a pathway for diagnosis and treatment which works, but the Ministry of Defence believes more research needs to be done. “In the meantime, veterans are killing themselves in ever increasing numbers because they are wrongly diagnosed.”

 

A brain injury summit held at the Centre for Blast Injury Studies at Imperial College in London in January was attended by international experts and members of the armed forces medical services. A draft report seen by the Sunday People concluded there is an “urgent operational need to address the issues arising out of large numbers of military personnel and veterans with symptoms of blast traumatic brain injuries”.

 

But the MoD has been calling for more research since 2007 when the problem first surfaced in the US. Tory MP Dr Liam Fox, who at the time was shadow defence secretary, said then that the failure by the MoD to properly treat TBI victims was a dereliction of duty. He said: “Why should US troops be getting better care than British troops?”

 

Since 2007, thousands of US soldiers have been treated for the condition and are now able to lead relatively ­normal lives. Treatment involves stimulating the brain with a magnetic field, then mapping it with a MEG scanner, followed by a course of endocrine hormones. In the UK, this would cost around £1,500 to £2,000 per patient – a similar amount to that in the US.

Dr. Mark L. Gordon

Dr Mark Gordon, who runs the Millennium Health Centres in Los Angeles, has treated US Navy Seal special forces and attended the brain injury summit in the UK in January.

He gave three SAS members and a Royal Marine a grant worth £2,500 so they could get his treatment. He said: “As far as I am aware, they are all doing really well. We have a 75 per cent success rate so far. Most ­people see a significant improvement within 90 days of treatment.

“We have treated 348 military, from foot soldiers to a rear admiral, and they have returned to full activities.”

 

Recent advances in science have shown that a TBI caused by a blast is different to that caused by concussion. Symptoms of blast TBI include tiredness, dizziness, aggression, memory loss, sleeplessness and problems concentrating. The condition can also lead to ­physical child and domestic abuse.

 

Scientists claim that many sufferers end up in prison. In the UK, there are believed to be at least 3,000 veterans in jail but some estimates suggest the number is far higher. So far this year, there have been 49 self-inflicted deaths among veterans and serving personnel, and more than 200 since 2017. Former Royal Marine Jeff Williams of Veterans United Against Suicide said: “This is an absolute scandal. Why are British troops not getting the same treatment as their US comrades? This is all down to money.”

 

One leading UK brain specialist, who asked not to be named, said he was appalled by the MoD’s attitude. Members of the Commons defence select committee are also concerned and are set to hear evidence from Ms Bostwick next month. She said: “Until we have accurate assessment, diagnosis and treatment with support for families, thousands suffering a blast injury to the brain will continue to be misdiagnosed and channelled into mental health services, leaving them at high risk of suicide.”

 

The MoD said: “We have a dedicated treatment programme for traumatic brain injuries and are leading research into the diagnosis, management and rehabilitation of patients.”

 

Source: Mirror UK

BRAIN CARE II – The Emerging Science of Coronavirus Defense The Covid-19 Paradox

A word from Dr. Mark L. Gordon, AJT Holdings Group Lead Medical Director

Non-Traumatic Brain Injury or Viral Encephalopathy

Well it was anticipated and just a matter of time before the reports started appearing about the neurological impact of Covid-19 on the brain. Those of you who have been following my work on traumatic and non-traumatic brain injuries(1) are now going to be witnessing the rise of neuropsychiatric conditions in association with the coronavirus. This is the non-traumatic form of brain injury being precipitated by Covid-19 that induces a massive release of inflammatory cytokines being referred to as “Cytokine Storm” or actually Autoimmune Encephalitis(2). This is being exacerbated by a secondary viral infection of the brain or Viral Encephalitis(3).

Dr. Jennifer Frontera, a neurologist at NYU Langone Brooklyn hospital is seeing coronavirus patients with impact on the brain and nervous system. Additionally, Dr. Frontera’s team is documenting cases including seizures in COVID-19 patients with no prior history of epilepsy, and “unique” new patterns of tiny brain hemorrhages(4). In some cases, significant damage to the white matter of the brain is seen causing varied degrees of brain damage(5). A study published in the Journal of the American Medical Association last week found 36.4 percent of 214 Chinese patients had neurological symptoms ranging from loss of smell and nerve pain, to seizures and strokes(6). A paper in the New England Journal of Medicine this week examining 58 patients in Strasbourg, France found that more than half were confused or agitated, with brain imaging suggesting inflammation(7).

“We’re seeing a lot of consults of patients presenting in confusional states,” Dr. Rohan Arora, a neurologist at the Long Island Jewish Forest Hills hospital told AFP, saying that more than 40 percent of recovered Covid-19 patients exhibit altered levels of consciousness(8).

As in our veterans exposed to a spectrum of battle injuries, sports professionals on the field of play getting their “bell rung”, and civilians living and enjoying life to the fullest, there are moments of injury that are negated because they did not cause loss of consciousness, amnesia, or nausea/vomiting, but initiated a process of neuroinflammation. Neuroinflammation can be acute being associated with or without short-term neurological, cognitive, and neurobehavioral disorders(9),(10) or long-term with chronic symptomatology. As long as there is inflammation, there are Cytokines.

The Mechanisms of Damage

There are three major pathways that a virus, such as the Covid-19, can lead to neurological involvement of the brain with alterations in psychological, physiological, and physical functioning. The first, is the response of the body’s immune system directed against the invading Coronavirus. As has been seen in the elderly, those with a compromised immune systems, diabetes, multiple medical conditions and medication, there is a hyperbolic response of the immune system leading to a “Cytokine Storm”
throughout the body with the greatest impact on the respiratory system(11). It is a rapid process in many compromised individuals, moderate in some, mild in others, and in the fortunate without a missed beat. As the ability of our lungs to take in oxygen and expel carbon dioxide fails, a condition known as hypoxia looms. As hypoxia worsens, the lack of oxygen in the brain causes a loss of Fractalkine, a Chemokine that lowers the brains’ production of cytokines from the Microglia cells(5),(12). Loss of Fractalkine allows for brain derived cytokines to be released in another “Cytokine Storm”(13).

A second pathway is derived from damage to the blood brain barrier (BBB) that protects the brain from products or infections circulating below the neck. Disruption of the BBB by the presence of elevating levels of cytokines(14) produced below the neck along with those being produced by the glial cells of the brain, allows for the passage of Covid-19 into the brain to initiate a viral encephopathy(15).

The third pathway is a cumulative effect of cytokines on the molecular chemistry of the brain. Neuroinflammation leads to elevation in ROS/RNS causing a rise in the level of oxidative stress (oxidative load) which impedes the normal biochemical processes required for cell-to-cell communication(16). This can be clinically observed as a change in level of consciousness, cognition, and neuropsychobehavior(17).

As you can see from these three key pathways, they overlap in their ability to create a non-neuropermissive environment leading to the loss of neuronal and lobar functioning. If left unchecked, the ultimate effect of Covid-19 on those surviving will be a population of individuals with diminished mental and physical capacity to live independently and without medication; a scenario we see consistently at initiation of treatment with our Veteran Heroes.

Treatment

The Millennium-TBI Project has been addressing the neuroinflammation generated by traumatic and non-traumatic injuries with nutraceutical products such as eicosanoids(18), tocopherols(19), NAC(20), melatonin(21), quercetin(22), and EGCG(23), all showing their ability to lower the production of inflammatory cytokines while protecting neurons and glial cells from oxidative stress.

References:
1. Traumatic Brain Injury: A clinical approach to diagnosis and treatment. 2015. Mark L. Gordon, MD. Millennium-Phoenix
Publishing, Beverly Hills, California. 2015. ISBN: 978-0-9904630-1-6.
2. Into the Eye of the Cytokine Storm 2012. [MMBReview]
3. Neuroinfection may potentially contribute to pathophysiology and clinical manifestations of COVID-19. [Acta Physiologica]
4. Small Subset of People with COVID-19 Display Neurological Symptoms. [NY Times]
5. Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease. [PUBMED]
6. Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China. [JAMA]
7. Neurologic Features in Severe SARS-CoV-2 Infection. [NEJM]
8. Confusion, seizure, strokes: How COVID-19 may affect the brain. [AFP]
9. Neuroinflammation and psychiatric illness. [JNI]
10. The Role of Inflammation and microglial activation in the pathophysiology of psychiatric disorders. [NeuroScience]
11. Induction of Pro-Inflammatory Cytokines (IL-1 and IL-6) and Lung Inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): Anti-Inflammatory Strategies [PUBMED]
12. The Effects of Hypoxia and Inflammation on Synaptic Signaling in the CNS. [Neuroimmune]
13. Control of microglial neurotoxicity by the fractalkine receptor. [PUBMED]
14. Blood-brain barrier pathophysiology in traumatic brain injury. [StrokeRes]
15. Neurological Complications of Coronavirus Disease (COVID-19): Encephalopathy [Article]
16. Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation. [BiochemSoc]
17. Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential
immunologic mechanisms. [PUBMED]
18. Neuroprotection for the Warrior: Dietary Supplementation with Omega-3 Fatty Acids. [PUBMED]
19. Modulation of inflammation in brain: a matter of fat. [PUBMED]
20. N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities. [PUBMED]
21. COVID-19: Melatonin as a potential adjuvant treatment. [PUBMED]
22. In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-
regulation of the NF-kB pathway. [WILEY]
23. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives, and clinical applications. [PUBMED]

Pandemic-associated Psychological Distress

Under the influence of psychological stressors there is a spontaneous increase in microglial production of inflammatory cytokines such as IL-1, IL-1B, IL-6 and TNF-alpha. This is brought about by the downregulation of the chemokine, Fractalkine, by cortisol and corticotropin stimulating hormone. Without Fractalkine, its microglial receptors are vacant and the transcriptional trigger for inflammatory cytokines, NF-kB, is set in motion with the production of cytokines. Modulation of NF-kB’s ability to initiate translation of the cytokines is the focus of the nutraceutical components of the product Brain Care II. Available on Amazon while supplies last.

PRICE LIST | Hygienic Disinfectant Solution – Protection against COVID-19

Using the right type of disinfectant regularly on surfaces throughout your facility is critical in helping prevent the spread of colds, flu and other illnesses.

More effective than fogging, our smoke disinfectant technique uses a dry disinfectant smoke system spraying 0.1 – 0.2 fine micron particles which kills germs and viruses more efficiently on living objects in your home or office space.

การใช้น้ำยาฆ่าเชื้อชนิดที่เหมาะสมเป็นประจำ บนพื้นผิวทั่วไปและพื้นที่ใช้สอยเพื่อช่วยในการป้องกันการแพร่กระจายและยับยั้งไวรัส (Covid-19) รวมถึงไวรัสสายพันธุ์ต่างๆ และแบคทีเรีย

มีประสิทธิภาพมากกว่าด้วยวิธีการพ่นน้ำยาด้วยระบบควันที่มีอนุภาคละเอียดขนาด 0.1-0.2 ไมครอน ซึ่งมีประสิทธิภาพสูงสามารถฆ่าแบคทีเรียได้อย่างเต็มอนุภาพ

Contact / ติดต่อ
Line : http://line.me/ti/p/@ajtholdings
Call : 091-956-1615, 02-077-7866
Email : info@ajtholdings.com

Hygienic Disinfectant Solution บริการพ่นน้ำยาฆ่าเชื้อระบบควัน เพื่อป้องกัน COVID-19

Using the right type of disinfectant regularly on surfaces throughout your facility is critical in helping prevent the spread of colds, flu and other illnesses.

More effective than fogging, our smoke disinfectant technique uses a dry disinfectant smoke system spraying 0.1 – 0.2 fine micron particles which kills germs and viruses more efficiently on living objects in your home or office space.

การใช้น้ำยาฆ่าเชื้อชนิดที่เหมาะสมเป็นประจำ บนพื้นผิวทั่วไปและพื้นที่ใช้สอยเพื่อช่วยในการป้องกันการแพร่กระจายและยับยั้งไวรัส (Covid-19) รวมถึงไวรัสสายพันธุ์ต่างๆ และแบคทีเรีย

มีประสิทธิภาพมากกว่าด้วยวิธีการพ่นน้ำยาด้วยระบบควันที่มีอนุภาคละเอียดขนาด 0.1-0.2 ไมครอน ซึ่งมีประสิทธิภาพสูงสามารถฆ่าแบคทีเรียได้อย่างเต็มอนุภาพ

Contact / ติดต่อ
Line : http://line.me/ti/p/@ajtholdings
Call : 091-956-1615, 02-077-7866
Email : info@ajtholdings.com

[Thai Below]