BRAIN CARE II – The Emerging Science of Coronavirus Defense The Covid-19 Paradox

A word from Dr. Mark L. Gordon, AJT Holdings Group Lead Medical Director

Non-Traumatic Brain Injury or Viral Encephalopathy

Well it was anticipated and just a matter of time before the reports started appearing about the neurological impact of Covid-19 on the brain. Those of you who have been following my work on traumatic and non-traumatic brain injuries(1) are now going to be witnessing the rise of neuropsychiatric conditions in association with the coronavirus. This is the non-traumatic form of brain injury being precipitated by Covid-19 that induces a massive release of inflammatory cytokines being referred to as “Cytokine Storm” or actually Autoimmune Encephalitis(2). This is being exacerbated by a secondary viral infection of the brain or Viral Encephalitis(3).

Dr. Jennifer Frontera, a neurologist at NYU Langone Brooklyn hospital is seeing coronavirus patients with impact on the brain and nervous system. Additionally, Dr. Frontera’s team is documenting cases including seizures in COVID-19 patients with no prior history of epilepsy, and “unique” new patterns of tiny brain hemorrhages(4). In some cases, significant damage to the white matter of the brain is seen causing varied degrees of brain damage(5). A study published in the Journal of the American Medical Association last week found 36.4 percent of 214 Chinese patients had neurological symptoms ranging from loss of smell and nerve pain, to seizures and strokes(6). A paper in the New England Journal of Medicine this week examining 58 patients in Strasbourg, France found that more than half were confused or agitated, with brain imaging suggesting inflammation(7).

“We’re seeing a lot of consults of patients presenting in confusional states,” Dr. Rohan Arora, a neurologist at the Long Island Jewish Forest Hills hospital told AFP, saying that more than 40 percent of recovered Covid-19 patients exhibit altered levels of consciousness(8).

As in our veterans exposed to a spectrum of battle injuries, sports professionals on the field of play getting their “bell rung”, and civilians living and enjoying life to the fullest, there are moments of injury that are negated because they did not cause loss of consciousness, amnesia, or nausea/vomiting, but initiated a process of neuroinflammation. Neuroinflammation can be acute being associated with or without short-term neurological, cognitive, and neurobehavioral disorders(9),(10) or long-term with chronic symptomatology. As long as there is inflammation, there are Cytokines.

The Mechanisms of Damage

There are three major pathways that a virus, such as the Covid-19, can lead to neurological involvement of the brain with alterations in psychological, physiological, and physical functioning. The first, is the response of the body’s immune system directed against the invading Coronavirus. As has been seen in the elderly, those with a compromised immune systems, diabetes, multiple medical conditions and medication, there is a hyperbolic response of the immune system leading to a “Cytokine Storm”
throughout the body with the greatest impact on the respiratory system(11). It is a rapid process in many compromised individuals, moderate in some, mild in others, and in the fortunate without a missed beat. As the ability of our lungs to take in oxygen and expel carbon dioxide fails, a condition known as hypoxia looms. As hypoxia worsens, the lack of oxygen in the brain causes a loss of Fractalkine, a Chemokine that lowers the brains’ production of cytokines from the Microglia cells(5),(12). Loss of Fractalkine allows for brain derived cytokines to be released in another “Cytokine Storm”(13).

A second pathway is derived from damage to the blood brain barrier (BBB) that protects the brain from products or infections circulating below the neck. Disruption of the BBB by the presence of elevating levels of cytokines(14) produced below the neck along with those being produced by the glial cells of the brain, allows for the passage of Covid-19 into the brain to initiate a viral encephopathy(15).

The third pathway is a cumulative effect of cytokines on the molecular chemistry of the brain. Neuroinflammation leads to elevation in ROS/RNS causing a rise in the level of oxidative stress (oxidative load) which impedes the normal biochemical processes required for cell-to-cell communication(16). This can be clinically observed as a change in level of consciousness, cognition, and neuropsychobehavior(17).

As you can see from these three key pathways, they overlap in their ability to create a non-neuropermissive environment leading to the loss of neuronal and lobar functioning. If left unchecked, the ultimate effect of Covid-19 on those surviving will be a population of individuals with diminished mental and physical capacity to live independently and without medication; a scenario we see consistently at initiation of treatment with our Veteran Heroes.

Treatment

The Millennium-TBI Project has been addressing the neuroinflammation generated by traumatic and non-traumatic injuries with nutraceutical products such as eicosanoids(18), tocopherols(19), NAC(20), melatonin(21), quercetin(22), and EGCG(23), all showing their ability to lower the production of inflammatory cytokines while protecting neurons and glial cells from oxidative stress.

References:
1. Traumatic Brain Injury: A clinical approach to diagnosis and treatment. 2015. Mark L. Gordon, MD. Millennium-Phoenix
Publishing, Beverly Hills, California. 2015. ISBN: 978-0-9904630-1-6.
2. Into the Eye of the Cytokine Storm 2012. [MMBReview]
3. Neuroinfection may potentially contribute to pathophysiology and clinical manifestations of COVID-19. [Acta Physiologica]
4. Small Subset of People with COVID-19 Display Neurological Symptoms. [NY Times]
5. Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease. [PUBMED]
6. Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China. [JAMA]
7. Neurologic Features in Severe SARS-CoV-2 Infection. [NEJM]
8. Confusion, seizure, strokes: How COVID-19 may affect the brain. [AFP]
9. Neuroinflammation and psychiatric illness. [JNI]
10. The Role of Inflammation and microglial activation in the pathophysiology of psychiatric disorders. [NeuroScience]
11. Induction of Pro-Inflammatory Cytokines (IL-1 and IL-6) and Lung Inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): Anti-Inflammatory Strategies [PUBMED]
12. The Effects of Hypoxia and Inflammation on Synaptic Signaling in the CNS. [Neuroimmune]
13. Control of microglial neurotoxicity by the fractalkine receptor. [PUBMED]
14. Blood-brain barrier pathophysiology in traumatic brain injury. [StrokeRes]
15. Neurological Complications of Coronavirus Disease (COVID-19): Encephalopathy [Article]
16. Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation. [BiochemSoc]
17. Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential
immunologic mechanisms. [PUBMED]
18. Neuroprotection for the Warrior: Dietary Supplementation with Omega-3 Fatty Acids. [PUBMED]
19. Modulation of inflammation in brain: a matter of fat. [PUBMED]
20. N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities. [PUBMED]
21. COVID-19: Melatonin as a potential adjuvant treatment. [PUBMED]
22. In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-
regulation of the NF-kB pathway. [WILEY]
23. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives, and clinical applications. [PUBMED]

Pandemic-associated Psychological Distress

Under the influence of psychological stressors there is a spontaneous increase in microglial production of inflammatory cytokines such as IL-1, IL-1B, IL-6 and TNF-alpha. This is brought about by the downregulation of the chemokine, Fractalkine, by cortisol and corticotropin stimulating hormone. Without Fractalkine, its microglial receptors are vacant and the transcriptional trigger for inflammatory cytokines, NF-kB, is set in motion with the production of cytokines. Modulation of NF-kB’s ability to initiate translation of the cytokines is the focus of the nutraceutical components of the product Brain Care II. Available on Amazon while supplies last.

PRICE LIST | Hygienic Disinfectant Solution – Protection against COVID-19

Using the right type of disinfectant regularly on surfaces throughout your facility is critical in helping prevent the spread of colds, flu and other illnesses.

More effective than fogging, our smoke disinfectant technique uses a dry disinfectant smoke system spraying 0.1 – 0.2 fine micron particles which kills germs and viruses more efficiently on living objects in your home or office space.

การใช้น้ำยาฆ่าเชื้อชนิดที่เหมาะสมเป็นประจำ บนพื้นผิวทั่วไปและพื้นที่ใช้สอยเพื่อช่วยในการป้องกันการแพร่กระจายและยับยั้งไวรัส (Covid-19) รวมถึงไวรัสสายพันธุ์ต่างๆ และแบคทีเรีย

มีประสิทธิภาพมากกว่าด้วยวิธีการพ่นน้ำยาด้วยระบบควันที่มีอนุภาคละเอียดขนาด 0.1-0.2 ไมครอน ซึ่งมีประสิทธิภาพสูงสามารถฆ่าแบคทีเรียได้อย่างเต็มอนุภาพ

Contact / ติดต่อ
Line : http://line.me/ti/p/@ajtholdings
Call : 091-956-1615, 02-077-7866
Email : info@ajtholdings.com

Hygienic Disinfectant Solution บริการพ่นน้ำยาฆ่าเชื้อระบบควัน เพื่อป้องกัน COVID-19

Using the right type of disinfectant regularly on surfaces throughout your facility is critical in helping prevent the spread of colds, flu and other illnesses.

More effective than fogging, our smoke disinfectant technique uses a dry disinfectant smoke system spraying 0.1 – 0.2 fine micron particles which kills germs and viruses more efficiently on living objects in your home or office space.

การใช้น้ำยาฆ่าเชื้อชนิดที่เหมาะสมเป็นประจำ บนพื้นผิวทั่วไปและพื้นที่ใช้สอยเพื่อช่วยในการป้องกันการแพร่กระจายและยับยั้งไวรัส (Covid-19) รวมถึงไวรัสสายพันธุ์ต่างๆ และแบคทีเรีย

มีประสิทธิภาพมากกว่าด้วยวิธีการพ่นน้ำยาด้วยระบบควันที่มีอนุภาคละเอียดขนาด 0.1-0.2 ไมครอน ซึ่งมีประสิทธิภาพสูงสามารถฆ่าแบคทีเรียได้อย่างเต็มอนุภาพ

Contact / ติดต่อ
Line : http://line.me/ti/p/@ajtholdings
Call : 091-956-1615, 02-077-7866
Email : info@ajtholdings.com

[Thai Below]

 

STAYING PHYSICALLY AND MENTALLY HEALTHY WHILE COVID-19 HAS YOU STUCK AT HOME

Going back to basics, most health tips boil down to simple actions such as being hygienic, exercising, eating a balanced diet and getting adequate amount of sleep.

Especially during a pandemic like COVID-19, these behaviours are especially important for maintaining your physical and mental wellbeing.

Here’s how to stay healthy both mentally and physically while social distancing during the COVID-19 outbreak.

 

NUTRITION

Plan before you stock up on groceries. This ensures you pick up the right things, and to avoid panic-buying and wiping out community supplies. Before you add an item to cart, create your meal plan consisting of a starch, a protein and produce.

Now, more than ever, is a good time to buy fresh produce. You can always put them in the freezer and use them for months to come. Sturdy vegetables and starches like broccoli, Brussels sprouts and sweet potatoes also keep for a long time outside the freezer.

If you do buy canned, dried or frozen goods, choose those low in saturated fat, salt and added sugars.

As far as nutrition goes, lastly, avoid boredom and stress eating. And if you must, choose to snack on healthier titbits such as fruits and nuts.

 

FITNESS

You may not be able to go to the gym, but it’s okay to walk, or work-out in the comfort of your home. Streaming services make it a little easier to stay active even when gyms and fitness studios are off-limits. In case you missed last month’s article we’ve listed some of The Best Fitness Apps to Keep You Well During the Coronavirus Lockdown.

 

Improvise, Improvise, Improvise!

Get creative and fill a tote or backpack for weights, dish towels for sliders (for exercises like lunges and mountain climbers) or a strong, steady chair for step-ups.

Take comfort in the fact that physical activity doesn’t have to mean a gym style workout. It could be everyday activities like walking, gardening and cleaning — any amount of movement you can squeeze in matters.

 

CLEANING

According to research, the virus that causes COVID 19 can survive on plastic and stainless-steel surfaces for up to 72 hours, cardboard for 24 hours and copper for 4 hours.

Hence, even in your own home, keep clean and hygienic by wiping down high-touch objects like doorknobs and faucets, in addition to regular household upkeep.

Washing your hand and bath towels regularly as well as removing your shoes as soon as you get home helps.

Decluttering is also crucial, especially if you live in a small space. It will make you feel good as decluttering makes your space feel larger and more comfortable, and even more so, less items to touch that could potentially transmit germs.

For an added peace of mind, there are now several Disinfectant and Sanitisation Solutions available for home and office owners. Using the right types of disinfectants regularly on surfaces throughout your facility is critical in helping prevent the spread of colds, flu, and other illnesses.

 

STRESS & SLEEP

Managing stress and anxiety is vital for getting adequate sleep—and getting adequate sleep is important for overall health.

Meditation and yoga are great tools for managing stress, and they can be done in a smaller space. You can also turn to apps like Headspace and Let’s Meditate for virtual mindfulness therapy.

Wellness environment also plays an important role – try setting aside an area in your home that’s free of technology, except for perhaps a speaker for music. Design your space with items that can calm you such as scented candles, indoor plants and cushions. Creating a quiet space to reflect, away from the over-exposure to the chaos, can help to decrease the anxiety.

If you’re working from home, as far as possible, designate separate areas for work and personal life in order to mentally separate components of your day.

Balance that quiet time with responsible social interaction, such as using WhatsApp or Line video call can help you feel less isolate when you’re alone at home.

The Best Fitness Apps to Keep You Well During the Coronavirus Lockdown

These streaming services make it a little easier to stay active even when gyms and fitness studios are off-limits. Even more so during times like these, it’s time to get those endorphins going!

Right now, is a better time than ever to work out and meditate at home. On YouTube, you can join millions of subscribers in following, Yoga with Kassandra, POPSUGAR Fitness, OR Yoga With Adriene for accessible instructional videos.

If you can, set aside 30 minutes a day for exercise, and by mixing things up with a variety of workout routines and meditation your body naturally releases chemicals called endorphins. These endorphins interact with the receptors in your brain that reduce your perception of pain and trigger a positive feeling in the body. To stay motivated, look for an exercise buddy, be it a close friend, loved ones, or new friend via social media.

Fitness apps:
Alo Moves
Keep – Home Workout Trainer
SWEAT: Kayla Itsines Fitness
Barre Body Online

Meditation apps:
Headspace: Mediation & Sleep
Let’s Mediate: Sleep & Guided Meditation
Stop, Breathe & Think: Meditation & Mindfulness

The Emerging Science of Coronavirus Defense The Covid-19 Paradox

By Dr. Mark L. Gordon, AJT Holdings Group Lead Medical Director | March 20, 2020

The sudden appearance in China of the novel coronavirus, now identified as Covid-19, has rapidly spread around the globe with a relatively small but rising death toll. Death from the infection is due to SARS, a severe acute respiratory syndrome, that effects the lungs ability to transport oxygen to our red blood cells. Contrasted to the annual fatalities from Influenza A, Covid-19 has presently paled in the total number of deaths in comparison.

We would like to believe that this is due to the rapid response by our government in identifying the location of origin, Wuhan China, but has not found Patient Zero (the index case or the first person to acquire the illness) which would help identified the originating source of the virus. Speculation exists that claim the Covid-19 virus was manufactured or that the virus jumped from animal to man, these are just that – speculations.

In the recent past, an epidemic with SARS (a coronavirus infection) originated in Guangdong China in 2003, resulted in more than 8000 cases in 26 countries with 774 deaths. Since then, a small number of cases have occurred as a result of laboratory accidents or, possibly, through animal-to-human transmission according to the WHO.

Now, we know what we are dealing with a virus, and the question becomes how best to protect ourselves from becoming infected with the virus. With that question asked, we need to take a short course in virology to understand how we might be able to protect ourselves and our loved ones.

 

How Viruses infect our cells

Viruses are a unique adversary to human wellness since they need to utilize our own cells’ systems to replicate their genome. Once the virus injects its RNA (ribose nucleic acid) into our cell, it utilizes our protein manufacturing centers called ribosomes to recreate and multiply this protein which is called Replicase (RNA dependent RNA polymerase). It is Replicase that directs our cells to continue to manufacture the viral genome and structural proteins. The coronavirus replication cycle is divided into several steps: attachment and entry, translation of viral replicase, genome transcription and replication, translation of structural proteins, and virion assembly and release.

Therefore, the question is how best to stop this process? Enter zinc, which has been found to inhibit the production of Replicase. Without replicase there cannot be replication of the viral genome, but there is a problem with getting zinc into the cell. Zinc is a mineral that has an electric charge making it an ion; an atom or molecule with a net electric charge; zinc has a plus 2 charge (ZN+2). Due to this electric charge, zinc cannot easily cross the cell membrane and enter the cell to stop the replicase production.

 

The Ionophore Carrier

The membranous outer surface of our cells is a bi-lipid layer that controls the entrance as well as exit of compounds in and out of our cells. Some compounds pass easily into the cell while others cannot transverse the membrane due to their size or an electrical charge. The presence of an electric charge impedes their passage through the bi-lipid cell membrane and mandates that they be chaperoned or carried into the cell by a substance called an Ionophore.

Ionophore means “ion carrier” and represents a diverse group of compounds that catalyze ion transport across hydrophobic membranes such as those making up our cells. These carrier ionophores may be proteins or other molecules, pharmaceuticals or nutraceuticals.

In order to get these compounds from the outside of the cell to the inside, a virtual transmembrane channel is needed. These highly selective transmembrane passageways allow for the transport of charged particles, ions, into the cell, but they need a carrier or transport molecule to facilitate their passage. Without a transporter, the product to be delivered is stuck on the outside of the cell membrane never to gain entrance.

Fortunately, zinc has been found to be transported into the cell by a number of medications and natural products or nutraceuticals. Presently, the anti-malarial medication Chloroquine, has been found to be an ionophoric transporter of zinc. In the coming days more information will come out about this medication with potential side-effects. In the nutraceutical realm both Quercetin and Epigallocatechin gallate (EGCG) are capable of ionotropic transport of zinc into the cell without toxic side-effects.

The three types of zinc supplements most easily absorbed by the body which are zinc picolinate, zinc acetate, and zinc citrate. Once the zinc is absorbed through the intestinal lining into the blood stream it becomes the responsibility of either the EGCG or Quercetin to act as the ionophore transporter to get it into the cell. Once Zinc is in the cell it can address the disruption of the viral replication mechanism by inhibiting replicase’s production.

Based upon this science, it appears if the combination of Quercetin, EGCG, and Zinc are taken pre-infection the cells are prepared for the attempted invasion of the viral genetic material into our cells. If you have not prepared your cells, the only benefits will be in curtailing the further replication of the viral particles if the virus has already gained a foothold in your cells and is using your ribosomal-protein synthesis mechanism to make more virus. As always, an ounce of prevention goes a long way.

Suggested order of viewing: #2 and #3 to learn about viral replication, Zinc, and ionophore transport. Then #5 to understand how both safe and beneficial the nutraceuticals Quercetin and EGCG are as Ionophore carriers followed with # 6 and #7 the existence of science since 2003 about the benefits of Quercetin on stopping the cellular infection by Coronavirus and Ebola. To amplify the information then go to #4, #8, and the intense #9.

Over-view I believe that the point of convergence, for all this information, will be that Quercetin acts as an ionophore to carry zinc into the cell to inhibit viral genomic replication.

  1. World Health Organizations, SARS 2002.
  2. Dr. Roger Seheult explains how the Coronavirus infects our cells
  3. Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture
  4. Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase
  5. Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model 
  6. Newspaper article: A made-in-Canada solution to the coronavirus outbreak?
  7. CBS NEWS Canada: Quercetin and Dr. Michel Chrétien’s team at the Clinical Research Institute of Montreal
  8. The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing , E J Snijder, E Decroly , J Ziebuhr , Adv Virus Res, 96, 59-126 
  9. Human Coronavirus: Host-Pathogen Interaction. To Sing Fung, Annua Rev Microbiology 2019. 73:529-57. 

Comments:

Since 2001, the Millennium has used Zinc as an aromatase inhibitor in lieu of the poisonous anastrozole. The standard dosing of the Zinc Citrate was 60 – 90 mg a day. After reading about the Mitochondriogenic effects of Quercetin in 2006 we started adding 500mg twice a day to our professional athletes to improve their endurance and recovery. We also learned that Quercetin, a polyphenolic natural derivative, also modulates the inflammatory cytokines thereby decreasing inflammation. In 2019, we released Brain Care II, a liposomal product, to deliver 6 anti-inflammatory products into the body to address the neuroinflammation generated by traumatic and non-traumatic brain injuries in our veterans. This product contains both Quercetin and EGCG, both Ionophores.

What we have observed in our patient population, based upon their monthly program questionnaires (MPQs), is a reduction in the occurrence, intensity and duration of the common annual influenzas and colds. Coincidental or science? As you will read, Dr. Michel Chrétien’s team has already shown with SARS (2003) and Ebola that Quercetin has altered the ability of these Viral Vectors to gain a foothold. Could it be that individuals with an optimal level of zinc who are also on Quercetin stand a better chance at defending their cells from the viral incursion? Only with further research will this be proven but the groundwork, as shared above, is already underway.

Expect to see a surge in reports about Chloroquine treatments and research in the coming hours, days and weeks.

AJT Holdings Pte Ltd – Top 50 Healthcare Companies Award

“Developing modern healthcare in mixed-use development properties as well as offering [preventative health and wellness education] back to the community”,

Anthony Jude Tan

, Founder & Group MD

Coronavirus | Good Hand Hygiene Practice & How to Wear your Mask | COVID-19

The best way to protect yourself against the novel strain of coronavirus (COVID-19) is to use the same measures usually used to guard against the common cold or flu.
Here we demonstrate the most effective way to keep your hands clean, how to properly put on a surgical face mask and proper removal of the mask.

AJT February 2020 Newsletter

The proper way to clean your hands and
put on a surgical face mask
Here we demonstrate the most effective way to keep your hands clean, how to properly put on a surgical face mask and proper removal of the mask.  
Singapore Specialists in Phnom Penh!
Singapore Medical Center Cambodia managed by DrMap, works with FEM Surgery, a surgical group practice of various specialties from Singapore, to bring Singapore standards of medical excellence to Cambodia.
For appointments, contact Singapore Medical Center (SGMC).

DrMap CEO, Anthony Jude Tan, speaks at the Annual Health Fair, US Embassy in Phnom Penh.

Site Visit to Samrong General Hospital

Led by Founder & Group MD Anthony Jude Tan, the team visited Samrong General Hospital this month, coupled with a fruitful initial meeting with Dr.med.Prapa Wongphaet, President of the Thai Medical and Wellness Tourism Association.

 

FEM Singapore Specialists have arrived in Phnom Penh!

FEM Singapore Specialists have arrived in Phnom Penh!

Singapore Medical Center Cambodia

managed by DrMap, works with FEM Surgery, a surgical group practice of various specialties from Singapore, to bring Singapore standards of medical excellence to Cambodia.